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research methods

Methods of the first investigation phase were the general for all patients in research.

I stage - prior to the beginning of carrying out of specific therapy morphological research of the personal computer and KM, histological and cytogenetic research of KM was carried out; a biochemical blood analysis (the general fiber, albuminous fractions, urea, a creatinine, bilirubin, electrolytes, aminotransferases,); a coagulogram; roentgenography of organs of a thorax; ultrasonic research of organs of an abdominal cavity (a liver, a lien, lymph nodes) and kidneys; an electrocardiogram; the urine analysis; bacteriological researches (crops from fauces, blood crops, urine crops).

Methods of research of the second stage differed depending on a therapy variant.

P a stage against replaceable haemocomponental and symptomatic therapy - the personal computer analysis (haemoglobin, erythrocytes, leucocytes, the leukocytic formula, thrombocytes) 1 time in 3 days, the biochemical analysis of blood 2 times a week, a coagulogram - once a week, the urine analysis daily, till the moment of indemnification of an anaemic syndrome and a menacing thrombocytopenia; morphological research of KM in 3-4 weeks.

II stage against XT small doses of Cytosarum and PHT - the personal computer analysis (haemoglobin, erythrocytes, leucocytes, the leukocytic formula, thrombocytes) in a day, the biochemical analysis of blood 2 times a week, a coagulogram-once a week, the urine analysis weekly, till the moment of an exit from a postcytostatic agranulocytosis; morphological and cytogenetic researches of KM in 3-4 weeks from the moment of the termination of course XT, without dependence from personal computer indicators. A X-ray inspection of organs of a thorax and

AT/Celeron 330 on which all subsequent processing and the analysis of the received image was made. The image for morfometricheskogo the analysis took out in format BMP. The further processing of the image made by means of the program Adobe Photoshop in operational system Windows - 98.

Sites of active and fatty KM were led round by black and red colour, accordingly. The led round contours allocated in the program Scion Image with command Dencity slice, then by means of instrument Magic stick from keeping within length ' perimetre and the area of the allocated contour.

The percent of active KM was calculated under the formula:

S active KM

% Active KM =------------------------------h Ю0 %

S the general KM

2.2.2.

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A source: KLIMJUK Stepan Ivanovich. MYELODISPLASTIC SYNDROME: SOME CLINICAL AND HEMATOLOGICAL PECULIARITIES OF THE COURSE AND CHOICE OF THERAPY. DISSERTATION for the degree of candidate of medical sciences. Moscow - 2004. 2004

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