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Conclusions

In the present work complex research of change of electrokinetic properties of kernels and a chromatin state, and also permeability of membranes of cages bukkalnogo an epithelium of the person, subject to the combined action of weak microwave radiance (900 MHz is executed,

3.7 GHz, 8 GHz) and biologically awake bonds: aromatic DNA - interkaljatorov, caffeine and С60 fullerena.

On the basis of the received results it is possible to draw following conclusions:

1. Character of reaction of cages bukkalnogo an epithelium on electromagnetic radiance of various characteristics is established: radiance of working frequency WiMAX (3.7 GHz) with varied vigour and exposition time, radiance of mobile phones (900 MHz) with various levels SAR, and also the response of cages to electrical and magnetic component EMI to frequency of 8 GHz on-separateness. The expressed condensation of a chromatin and augmentation of permeability of a cellular membrane as functions of time of an exposition with a characteristic threshold and saturation range was observed. Thus the electrical component of an electromagnetic field renders bolshee influence on augmentation geterohromatinizatsii in comparison with the magnetic.

2. Introduction in cages of aromatic DNA-interkaljatorov leads to condensation of a chromatin and decrease in electronegativity of cellular kernels, thus action of caffeine and DNK-not catenated С60 fullerena did not invoke visible changes of a state of a chromatin and electrokinetic properties of kernels. Influences of all investigated preparations on permeability of a cellular membrane it was revealed not.

3. At research of the combined action of electromagnetic radiance with DNK-catenated materials it is found sinergetichesky protektornyj the effect consisting in reduction of the cellular response, invoked by electromagnetic radiance and preparations separately. At action С60 fullerena and caffeine also it was observed protektornyj effect in relation to action of electromagnetic radiance on a chromatin of cages bukkalnogo an epithelium of the person. On the basis of the received results the conclusion that the possible mechanism of observable effects is not bound directly to a complex formation the Preparation-dnk has been drawn, and can be carried out by means of interaction of preparations with the irradiated water medium.

4. At the combined influence of DNA-interkaljatorov on neproliferirujushchie cages bukkalnogo an epithelium kontsentratsionno-dependent restoration of functional activity of a cellular kernel is revealed at introduction not modified C60 fullerena or caffeine. The received experimental dependences of quantity of beads of a heterochromatin on concentration C60 fullerena or caffeine are well described within the limits of the theory intertseptorno-protektornogo actions in which basis representation about two molecular processes lays: intertseptornom (heteroassociations) and protektornom.

5. Kontsentratsionno-dependent restoration of the cellular response is revealed at action of combinations Interkaljator-caffeine on proliferirujushchuju culture of shone bacteria P. leiognathi Sh1. It is shown, that the observable effect is similar to that Interkaljator-caffeine on neproliferirujushchih cages bukkalnogo an epithelium is found in systems that specifies in existence of the uniform mechanism of the combined action of aromatic bonds in which basis lays nekovalentnoe a complex formation of preparations with each other and from DNA.

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A source: Skamrova Galina Borisovna. COMBINED ACTION of WEAK MICROWAVE RADIANCE And DNK-SVJAZYVAJUSHCHIHSJA PREPARATIONS ON CAGES BUKKALNOGO of the EPITHELIUM of the PERSON. 2014

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