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influence of electromagnetic radiance on an expression of genes

Cellular responses depend on effecting of proteins-enzymes, key regulators of cellular metabolic activity. Albuminous frames are coded in DNA and effected by means of a transcriptional of genes in RNK and translations mrnk in squirrels (i.e.

a gene expression). RCH radiance can influence on mrnk at level of a transcriptional or protein production. Great volume of researches of influence EMI on an expression of genes has been spent on cages of mammals, and also on other phylums of cages.

It is considered, that influence RCH EMI on an expression of the genes bound to a cancer (protooncogenes and genes-supressorov of tumours) is absent or weak enough. In some researches, however, intercommunicated about a protooncogene expression in p53-scarce cages [90] and time augmentation of an expression of a gene egr-1 [74]. In spite of the fact that in the majority of works of negative influence EMI on an expression of genes it was not revealed [78, 132, 185, 277, 278], available works with positive takes should not be ignored, also as well as necessity of the further researches for this range.

Numerous researches have been devoted influence RCH EMI on stress proteins, in particular hsps [96, 97, 99, 154, 172, 182, 226, 260, 275]. Though results of these works are rather discordant, some positive takes in vitro [99, 182, 260] have been received.

In work [99] irradiating of solution albumina the bull whey with frequency of 3.7 GHz (15-20 mvt/kg within 3-48 hours at temperature from 25 to 45 °s) enhanced aggregation of protein depending on time and temperature that testifies that EMI is capable to variate konformatsiju proteins without the general heating. Later [86] specific influence of radiance has been noted at 8.5 GHz on the green fluorescent protein. Samples either were irradiated EMI or heated up by means of resistive heating. In each case heating led to decrease in intensity of fluorescence of protein, and the spectrum was displaced in red range. It has been thus noticed, that at identical rise in temperature, observable change of fluorescence prevailed in the irradiated sample that has been interpreted as not thermal effect RCH of radiance.

The bunch of explorers [166-168, 188, 189] had been noted change in an expression and fosforiljatsii proteins in two cellular lines while in work the [283] little changes observed in other cellular line, are explained by a random factor. Thus, now the accurate picture of the response of character of an expression of genes on EMI is not defined and available data do not allow to make generalising conclusions.

1.1.4.

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A source: Skamrova Galina Borisovna. COMBINED ACTION of WEAK MICROWAVE RADIANCE And DNK-SVJAZYVAJUSHCHIHSJA PREPARATIONS ON CAGES BUKKALNOGO of the EPITHELIUM of the PERSON. 2014

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