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a problem Urgency

Fluorescent diagnostics (FD) and photodynamic therapy (FDT) are the up-to-date, intensively developing methods of diagnostics and treatment of malignant new growths. Method FDT is grounded on selective accumulation in a tumoral fabric of the photosensitizer, capable light at local action with a wave length corresponding to its maximum of uptake, to generate the cytotoxic agents causing destruction of tumoral crates [46, 86, 193].

Experience of application of the first photosensitizers in clinical practice has allowed to formulate requirements to "ideal"

To the photosensitizer, including biological, photodynamic and himiko-technological measure. First of all, it is homogeneity and reproducibility of a chemical compound; low dark toxicity; high selectivity of accumulation in tumours and prompt deducing from normal fabrics; uptake in an optical window transparences of biological fabrics; a high quantum yield of production singletnogo oxygen [10, 139].

In spite of the fact that last decades tens the substances possessing fotosensibilizirujushchimi properties have been synthesised, many of them have essential deficiencies: the difficult nonuniform chemical compound; the long-term deduction in an organism that is the parent of the expressed skin phototoxicity; rather low selectivity of accumulation in a tumoral fabric; uptake in a gamut of lengths of waves of 600-700 nanometers with low coefficient of an extinction that allows to reach at carrying out FDT of biological efficiency in a fabric only on small depth. In this connection working out of the new

Photosensitizers still remains an actual problem.

As potential photosensitizers are actively explored linkings of various chemical classes: porfiriny and their analogues, hloriny, bakteriohloriny, tetraazaporfiriny, etc. [60]. Special interest is caused porfiraziny (tetraazaporfiriny) owing to presence in them by macrosystems of conjugation of double communications, and also abilities to form strong complexes with the majority of metals of periodic system. The considerable quantity porfirazinov with various lateral assistants and atoms of metal in a macrocycle [17] is known. Among metallokompleksov porfirazina are most studied as photosensitizers naftalotsianiny and ftalotsianiny zinc, aluminium and silicon.

Photosensitizer fluorescence is key property for its use with a view of diagnostics and the allocation control in an organism, and svobodnoradikalnye the responses started singletnym by oxygen, underlie its medical activity. For clinical oncology actual and unresolved there is also a question of the early control of efficiency of photodynamic therapy. In 2009 for the first time there was a conferring on use meso-replaced porfirinovogo a dimer as a photosensitizer for FDT, allowing to observe course of photodynamic process on change of intracellular viscosity [164]. Such possibility has appeared thanks to a unique combination for data fluorofora properties of a photosensitizer and the molecular curl. Distinctive line of the last is the strong dependence of parametres of fluorescence from viscosity of the medium, related to induced by light intramolecular gyration or intertwisting [115, 166]. As vjazkostnye properties of intracellular medium essentially vary in the course of photoinduced death of crates [164], such approach gives potential possibility to carry out in a live organism monitoring of photodynamic process in a mode of real time with application of a method fluorescent imidzhinga with recording of a lifetime of an excited state. Restrictions for introduction of [165] linkings featured in operation are exclusive complexity and dearness of its reception in industrial quantities.

In this connection, search and examination of the new linkings providing fluorescent diagnostics and photodynamic therapy with possibility of the early control of its efficiency, can be considered as one of actual problems of the up-to-date observational biology.

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A source: Shiljagina Natalia Jurevna. EXAMINATION TETRAARILTETRATSIANOPORFIRAZINOV As POTENTIAL PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY And FLUORESCENT DIAGNOSTICS. 2014

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