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the combined influence of electromagnetic radiance and biologically awake bonds onalive organisms.

Possible interaction EMI of a microwave range with chemical compounds including about the BASS, is of interest for explorers on the several causes: because of the increasing health hazard of the population bound to complex chemical atmosphere which have developed at present with constantly increasing intensity RCH of radiance; because of potential use of the combined influence of medical products and EMI in anticarcinogenic therapy, and also risk of the given approach for healthy cages [84].

Moreover, if it will be proved, that weak EMP can variate (to enhance or reduce) action of medical products, it will discover new horizons as in studying of mechanisms of not thermal action EMI, and in application weak EMP in medicinal therapy.

Since 70х years, the big attention has been given research of the combined influence of microwave radiance and medicinal materials on the excitatory system. The excitatory system carry to the most sensitive to influence EMP because of its huge bioelectrical activity. As consequence, the special interest has invoked the possible

sinergetichesky effect EMI and psychoawake materials.

In 70х years in works [73, 128, 230, 276] the effect of the combined influence of preparations on mice, rats and the rabbits irradiated microwave EMI for the first time has been found. In all works the augmentation of efficacyy of a preparation under the influence of EMI was observed. Authors have come to conclusion, that the effect of preparations can be regulated by short-term influence nizkointensivnogo microwave radiance even if EMP in itself does not render visible influence on biological object.

In works [120, 158] the effect also has been shown

Microwave radiance of low density of a stream of the vigour, shown in augmentation of efficacyy of action of preparations naloksona,

hlordiazepoksida and galoperidola on rats. Authors believe, that the given effect is observed owing to transmission of energy EMI dopamin-opiatnoj to brain system.

The next certificate of intensifying of medical and biologic action of medical products is shown in work [40]. At introduction rats antiholinesteraznyh preparations and an irradiating within 10 minutes accepted statistically significant reduction of a body temperature in comparison with various control bunches. Increase gipotermii in the presence of a microwave irradiating was observed also at introduction to rats of another powerful ingibitora atsetilholinesterazy.

Unlike thermal levels of influences where effect EMI can show in permeability augmentation krovemozgovogo a barrier [92, 141, 212], the mechanism of influence weak EMP on action of psychoawake preparations while remains obscure.

The bunch of scientists of Institute of microbiology and virology of D.K.Zabolotnogo NAN Ukraine had been spent a number of experiments on cages of various cultures of yeast [204, 271, 272]. Studying of biological effects of radiance at action of the stressful factor in a kind fungitsidnyh antibiotics has allowed authors to reveal protektornyj character of influence weak EMI which shows in increase of stability of microorganisms to action of antibiotics at a preliminary irradiating. Authors believe, that EMI leads to activation of the basic endocellular metabolic pathes which are responsible for conservation of integrity of biological system in the presence of unfavorable destructive environmental factors.

The similar protective role weak EMI different ranges of frequencies is described in a number of works, for example [23, 184].

Thus, in cages of yeast S. cerevisiae [131] it was not observed changes in mutations, recombinations or genomnoj stabilities in the presence of not aromatic cloudy metilmetansulfonata depending on presence EMI of a mobile phone.

The special attention it is necessary to give to the combined influence weak EMI with aromatic the BASS, namely from DNA-interkaljatorami. The given direction, besides application in medicinal therapy, at positive takes can confirm once again a hypothesis about possibility of influence EMI directly on DNA [196].

Contribution EMI to damage of DNA, induced doksorubitsinom, and kinetics of its restoration has been considered in work [287]. Results of the given research in vitro on V-limfoblastoidnyh cages of the person have shown, that EMI on frequency of 1.8 GHz directly did not invoke DNA damage, however could influence processes of a reparation of damages of DNA invoked doksorubitsinom somewhat. It can be bound to influence EMI on process ekstsizionnoj DNA repairs by removal of nucleotides, however this hypothesis demands the further experimental acknowledgement.

Nevertheless, at research of possible interaction EMI of a millimetric range with doksorubitsinom in work [84] similar effects were revealed not. Cages Chinese homjachka were exposed to an exposition doksorubitsina and EMI with frequency of 2.45 GHz during 2х hours. It has been confirmed, that EMI did not render significant influence on change of a state of the cages invoked by action of an antibiotic.

Also it has not been revealed sinergizma in mutual action of microwave radiance (2.45 GHz) and an aromatic cloudy of a proflavine in a series of experiments on lejkemicheskih cages of mice [180].

In Ushakov's work in the co-authorship with Beljaevym [269] the combined effect bromic etidija (1 mg/ml) and microwave radiance of circular polarisation on a chromatin of cages has been investigated by method AVZV. At an irradiating without bromic etidija levopoljarizovannoe radiance led to changes in konformatsii chromatin E.coli while pravopoljarizovannoe did not invoke any visible changes. At inkubatsii cages with bromic etidiem, the situation varied on the inverse: pravopoljarizovannoe EMI became more

Effective, than levopoljarizovannoe. These data testify that for reverberatory interaction with EMI the object of influence should possess hiralnoj asymmetry and be relaid between right and left hiralnymi forms. DNA satisfies to these conditions. It is known, that bromic etidy weakens negatively twirled loops of DNA and stabilises pravozakruchennuju the B-form of DNA [273]. That cultivation of cages with bromic etidiem led to considerable increase of effect pravopoljarizovannogo radiances well corresponds to this fact. At the same time, levopoljarizovannoe EMI also led the small contribution to observable effect. Probably, bromic etidy stabilises not all sequences of DNA responsible for interaction of the V-form with microwave radiance.

As a whole, existing not numerous data about the combined interaction the BASS and EMI are discordant enough. Apparently from the given subsection, the observable effect can depend both on a choice of biological object of research, and from conditions of irradiating EMI. As consequence, to reveal an overall picture and the mechanism of their interaction now for the present it is not obviously possible.

1.5.

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A source: Skamrova Galina Borisovna. COMBINED ACTION of WEAK MICROWAVE RADIANCE And DNK-SVJAZYVAJUSHCHIHSJA PREPARATIONS ON CAGES BUKKALNOGO of the EPITHELIUM of the PERSON. 2014

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