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search of functional distinctions endotelija in regions with various

Predisposition and degree of an atherosclerotic lesion

The results of experiments described in the previous section, two more features endotelija in regions with various predisposition to an atherosclerosis have revealed: unequal sensitivity to disturbing factors (atherosclerosis risk factors) and the variated ability to answer with lifting tsamf on specific activation.

It allows to assume, that functional activity of cages in these regions can differ and on other parametres of a metabolism. First of all, it concerns possible infringements of interaction EK with other phylums resident or the wandering cells occupying a vascular side - various populations of leucocytes and gladkomyshechnymi cages (GMK).

Inpouring through a monolayer endotelija, cages limfotsitarnogo and monotsitarno - makrofagalnogo parentages are capable to collect in subendotelialnom space and to form intimalnye infiltraty [Gerrity, 1981; Gimbrone et al, 1989, 1990; Ross, 1993]. Biologically awake substances, sekteriruemye these cages in an intim, are capable to variate cardinally functional status GMK, activating them proliferativnuju and (or) synthetic activity i.e. to promote development of an atherosclerotic lesion. Other target tsitokinov, synthesised by leucocytes, become vysheraspolozhennye endotelialnye cages. Meanwhile, if ability of leukocytic products to influence on GMK is investigated in detail enough the question on participation in these processes of various populations endotelija remains till now open.

It is known, that EK are capable to produce as activators, and ingibitory proliferativnoj and synthetic activity GMK. Their number concern trombotsitarnyj growth factor PDGF transforming rostovoj factor TGF-p, koloniestimulirujushchie factors and some other [Castello et al, 1981; DiCorletto, 1984; DiCorletto, Fox, 1988; Scott-Burden, Vanhoutte, 1993]. It means, that two bunches of materials take part in regulation GMK endoteliem raznonapravlennogo actions, at least, and change of activity of each of them can be a key part in infringement of functional status GMK. Available literary data testify, that in the conditions of joint cultivation endotely is ingibitorom proliferatsii GMK [Willems et al, 1982; Scott-Burden, Vanhoutte, 1993]. Meanwhile, till now
It is not known, whether the covering regions aortas with various predisposition to an atherosclerosis, and if - yes it can have what value from the point of view of locality and primary topography of development of atherosclerotic lesions in pots of the person differ on this parametre EK.

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A source: ROMANOV Jury Askoldovich. STRUCTURALLY FUNCTIONAL FEATURES ENDOTELIJA of the PERSON In NORM And AT the ATHEROSCLEROSIS. The dissertation on competition of a scientific degree of a Dr.Sci.Biol. Moscow - 2003. 2003

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