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Object of research

As modelling object for clinical researches working manufactures of Open Society "Салаватнефтеоргсинтез" have been chosen: firm fuel (geptila) (N=202) and etilbenzola-styrene (N=243) (Salavat), spent to 2001-2003 surveyed (85,3 %) have made the Basic share of the man at the age from 24 till 60 years which middle age is peer 45,60±8,35.

During work there were surveyed workers with the work experience on harmful manufacture from 8 till 40 years (the average experience of work has made 15±7,57 years). Pensioners, the former workers of the studied manufactures - 10 persons have been besides, surveyed. Women made 15,3 % from all surveyed, and, at the majority of them (91,3 %) the work experience in manufactures geptila and EBS has made more than 10 years. On ethnic structure workers represented the admixed sample of Russian and Tatars.

Data about duration of the seniority, the transferred diseases, presence of bad habits, and also about duration of contact to adverse production factors were registered at interrogation at the moment of a blood capture. Data on a state of health have been received at the analysis of out-patient cards of annual periodic medical inspections of workers. [I]

Complex clinical inspection of workers with use of functional and laboratory methods is spent by doctors medsanchasti and experts of the Ufa scientific research institute of medicine of work and a bionomics of the person (Gimranova G. G, Churmaitaeva S.H.). Working conditions of the working listed manufactures have been estimated together with Karimovoj L.K., Muldashevoj N.A.

Control group Salavat and Ufa have made 335 practically healthy faces, inhabitants of. As the basic criterion of selection in control group absence of professional contact to harmful chemical substances served. The age of individuals of control group varied from 18 to 65 le ї? Middle age of individuals of control group has made 45,12±10,57 years. Groups of the surveyed workers and the control were comparable on an age, sex and an ethnic accessory.

For an estimation of a state of health of the surveyed workers are used biochemical and hematological indicators of a functional condition of a liver. The maintenance in bloods of haemoglobin, erythrocytes, an ESR, quantities of leucocytes, the leukocytic formula, and also activity of cytoplasmatic enzymes - aspartate aminotransferases (ACT), alaninaminotranspherases (ALT) has been analysed. Pigmental structure estimated under the maintenance of bilirubin and its fractions.

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A source: Makarova Olga Vladimirovna. POLYMORPHISM OF ENZYME ENERGY ENERGY-TRANSFORMATION GENES IN WORKERS OF PETROCHEMICAL INDUSTRIES. Thesis for the degree of candidate of biological sciences. Ufa - 2004. 2004

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