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CONCLUSIONS

1. The radical resection with excision more than 96 % of volume of a tumour authentically improves duration indicators bezretsidivnogo the period and survival rate of patients with malignant gliomami, thus an authentic difference in frequency of development of postoperative complications at more radical intervention in comparison with a partial oncotomy is noted.

2. Application intraoperatsionnoj fluorescent diagnostics allows to raise authentically degree of radicalism of a resection malignant gliom, considerably to improve indicators of survival rate and bezretsidivnogo the period.

3. Various intensity of a luminescence of sites of a tumour in a strip of a wavelength of 635 nanometers has authentic communication with degree zlokachestvennosti formations. Thus, in cases physiological dozvolennosti the resection malignant gliom within tissues with absence of a luminescence in a visible part of a spectrum is expedient.

4. Taking into account absence of authentic negative influence on frequency of complications and quality of a life of patients malignant gliomami fluorescent navigation, is safe enough and effective method of augmentation of degree of radicalism of a surgical cytoreduction.

5. The developed diagnostic tables allow to estimate the forecast of survival rate of each concrete patient with malignant gliomami being based on preoperative data.

PRACTICAL REFERENCES

1. In cases physiological dozvolennosti the resection malignant gliom within tissues with absence of visible fluorescence is expedient at use intraoperatsionnoj fluorescent diagnostics with a preparation "Alasens".

2. At localisation malignant gliom close functionally significant zones of a brain the resection within tissues with intensive ruby-red fluorescence within surgical dozvolennosti is expedient.

3. For carrying out of differential diagnostics between an anaplastic astrocytoma and glioblastomoj in the preoperative period at each concrete patient it is expedient to use the offered diagnostic algorithm.

4. The offered prognostic algorithm allows to estimate objectively probability of the bad forecast of survival rate at the concrete patient with malignant gliomoj.

THE LIST OF REDUCTIONS

AA - anaplastic astrocytoma GB - glioblastoma

- Confidential interval

- Diagnostic factor

- Control group

KT - a computer tomography

MRT - a magnitno-resonant tomography

OG - the basic group

H'M - a brain tumour

OFEKT - one-photon emission computer tomography PET - pozitronno-issue tomography FD - fluorescent diagnostics SHK - a scale Karnovsky

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A source: Anokhina Julia Evgenevna. CLINICO-MORPHOLOGICAL OUTCOMES of the RESECTION MALIGNANT GLIOM the BRAIN With USE INTRAOPERATSIONNOJ of FLUORESCENT DIAGNOSTICS. The dissertation on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg - 2014. 2014

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