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the Molekuljarno-genetic markers studied in work

In the given work at patients defined molekuljarno-genetic changes in the tumoral tissue received intraoperatsionno, means genotipirovanija on polymorphisms of gene TYMS (R2/R3, G> C, Del6bp) and gene ТР53 (72 Arg> Pro, Ins16bp).

Polymorphisms of gene TYMS. HARDWARE enzyme participates in synthesis de novo nucleotides of a thymine and uratsila (dTMP, dUMP), DNA necessary for synthesis and is a target for medicines, in particular derivatives ftorpirimidinov. The HARDWARE expression is the key factor defining sensitivity to 5-FAUGH. The low expression of the HARDWARE at patients is bound to larger sensitivity to the spent treatment and on the contrary. In turn activity TC depends on polymorphisms of DNA which are in reguljatornoj areas and influence resistance to 5 - FAUGH [9,40,111].

Polymorphisms of gene TP53. TR 53 - the gene coding transkriptsionyj the factor which at damage genoma causes a delay of a cellular cycle in phase G1 and promotes an apoptosis. Polymorphisms of gene ТР53 influence activity of fiber р53 concerning an apoptosis induction, that, in turn, can change sensitivity to himiopreparatam and their efficiency. In this connection, the answer to chemotherapy can differ at the individuals carrying various on functional activity of an allele of genes, supervising processes of a reparation and an apoptosis [73,147].

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A source: Udilova Anastas Andreevna. SURGICAL TREATMENT SICK MESTNORASPROSTRANENNYM the CARCINOMA OF THE STOMACH, Taking into account CLINICO-MORPHOLOGICAL And MOLEKULJARNO-GENETIC FACTORS. The DISSERTATION on competition of a scientific degree of the candidate of medical sciences. Moscow - 2015. 2015

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