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3.3. The comparative analysis of sick HIV-infections with positive and negativedermal reaction to a tuberculin

Middle age in OG has made 27,80±1,44 years, in GS - 28,32±1,34 years, that is, on age patients OG and GS practically did not differ.

Given (tab. 13) obtained in the previous sections testify, that in GS (RM-) men (66 people, 40,2 %) have appeared in 1,5 times less, than in OG (68 people, 59,6 %).

Accordingly women with negative RM (GS) in 1,5 times more than with positive reaction to a tuberculin.

Table 13

Sexual structure of patients in the basic group and comparison group.

Floor The basic group Comparison group
abs. % abs. %
Men 68 59,6 66 40,2
Women 46 40,4 98 59,8
Total 114 100 164 100

Differences to a sexual sign are authentic (r < 0,03). Таким образом, мужчины в данном исследовании обладали большей чувствительностью к ту­беркулину, чем женщины в 1,5 раза.

Distribution of patients on limitation periods of revealing of a HIV-infection is presented in table 14. So, among the infected HIV in the range from 0 till 3 years between patients OG and GS the expressed differences are not present, their shares in both groups corresponded 71,0 % and 73,2 %, that is have included about 3/4 patients. In a subgroup of the patients infected in term from 3 till 4 years it becomes perceptible neyokotoroe (5,1 %) prevalence of patients from OG (16,7 %) over patients from GS (11,6 %). Thus in GS the patients consisting on the account of the city centre on struggle against AIDS from 4 till 5 years and more, have exceeded indicators in OG on 1,5 %, i.e. In group with negative RM them it has appeared a little more than in grupyope with positive RM.

Table 14

Term infitsi -

rovanija

The basic group Comparison group
abs. % % abs. % %
< 1 года 49 42,9 73 44,5
1-2 years 14 12,3 71,0 21 12,8 73,2
2-3 years 18 15,8 26 15,9
3-4 years 19 16,7 19 11,6
4-5 years 8 7,0 29,0 14 8,5 26,8
5 years 6 5,3 11 6,7
Total 114 100 100 164 100 100

Limitation periods of revealing of a HIV-infection at patients of the basic group and comparison group.

From here, correlation dependence between terms of a becoming infected of a HIV-infection and sensitivity to a tuberculin it is not received.

In OG infection with a HIV-infection has occurred sexual by at 29,8 % payotsientov, in GS - at 47,5 % of patients. The parenteral way of infection is taped at 70,1 % of patients from OG and at 52,5 % - from GS. It is important to notice, that in GS the sexual way of infection with a HIV-infection met in L, 5 times more often, than in OG.

Surveying groups of patients depending on a HIV-infection stage it is established, that the majority of patients OG (81,6 %) and GS (76,2 %) at the moment of research had stages of primary implications, namely 2Б and 2В (tab. 15). In OG the HIV-infection diagnosis, a stage 2Б is established at 38,6 % patsiyoentov, in GS - at 38,4 % of patients. The HIV-infection diagnosis, a stage 2В in GS konyostatirovan at 37,8 %, and in OG at 43,0 % of patients, that on 5,2 % more than in GS. Stages of secondary diseases (FOR, ZB, ZV) in GS (23,8 %) were registered on 5,4 % more often, than in OG (18,4 %).

Thus, for patients with negative RM a HIV-infection neskolyoko it was more often diagnosed in a stage of secondary diseases though dostoveryonyh differences between groups it is not received.

Table 15

Stages of a HIV-infection at patients of the basic group and comparison group.

Stage

HIV

The basic group Comparison group
abs. % abs. %
44 38,6 81,6 63 38,4 76,2
49 43,0 62 37,8
FOR 16 14,0 26 15,9
ZB 4 ' 3,5 18,4 8 4,9 23,8
ZV 1 0,9 5 3,0 -
Total 114 100 100 164 100 100

The above-stated proves to be true also presence opportunistic inyofektsy. So, in GS they are diagnosed at 1/3 sick (36,0 % - 59), in that vreyomja, as century OG at smaller quantity sick (29,8 % — 34), thus dostoveryonyh is not present differences.

Nevertheless, the comparative analysis between patients OG and GS has taped some differences in frequency AIDS-assotsiirovannyh of diseases (tab. 16). So, a HIV-encephalopathy the leading place in structure opportuyonisticheskih diseases as in OG (76,4 % — 26), and in GS (79,7 % — 47) belonged; neyoskolko is more rare, but also it is equally frequent in both groups it was taped oral and ezofagealnyj a candidiasis: in OG — 61,8 % (21), in GS — 67,8 % (40). The Gerpeticheyosky infection in GS (49,2 % - 29) was found out in 1,5 times more often, than in OG (32,4 % - 11). In 1,4 times more often in GS (37,3 % - 22), than in OG (26,5 % - 9) vyjavljayolas the TSMV-INFECTION. Frequency of detection of a toxoplasmosis in GS (11,7 %) in 2 times exceeded that in OG (5,9 %).

Peaked condylomas in GS (8,5 %) found out in 3 times more often, and a hairy leukoplakia (6,8 %) in 2,3 times more often, than in patients GS (2,9 %).

The analysis of the epidemiological anamnesis in both groups has shown, that in GS 100 % of patients a tuberculosis were not ill, and in OG 4,3 % of patients in the past have transferred a tuberculosis, from them of 81,0 % - a focal pulmonary tuberculosis.

Table 16

Opportunistic diseases at patients of the basic group and group sravyonenija.

The diagnosis The basic group Comparison group
abs. % abs. %
HIV-encephalopathy 26 76,4 47 79,7
Candidosis infection 21 61,8 40 67,8
gerpeticheskaja an infection 11 32,4 29 49,2
TSMV-INFECTION 9 26,5 22 37,3
Toxoplasmosis 2 5,9 7 11,7
Peaked condylomas 1 2,9 5 8,5
Hairy leukoplakia 1 2,9 4 6,8

The information on their contacts was necessary for an estimation of results of researches of specific reactance at sick HIV-infections with tuyoberkuleznymi patients. It is found out, that in OG such contacts had 43,9 % of patients, that in 2,3 times more than in GS - 18,9 % (r < 0,02). В обеих сравни­ваемых группах наиболее часто пациенты имели контакт с туберкулезными больными в местах лишения свободы: 72% в ОГ и 61,3% в ГС, причем в ОГ туберкулезный контакт в МЛС регистрировался на 11% чаще (табл. 17). При этом в ГС периодический контакт (с друзьями, знакомыми) -22,6% - выяв­лялся в 2 раза чаще, чем в ОГ - 10%. Частота семейного контакта была не­сколько выше в ОГ (16%) по сравнению с ГС (12,9%).

Thus, patients of the basic group more closely and authentically contacted to tubercular patients is more often.

At primary survey of 17,5 % of patients OG and 22 % of patients GS showed complaints.

Table 17

The characteristic of contacts to tubercular patients at patients of the basic group and comparison group.

Contact type The basic group Comparison group
abs. % abs. %
MLS 36 72,0 19 61,3
The family 8 16,0 4 12,9
Periodic (the friends familiar) 5 10,0 7 22,6
The room 1 2,0 1 3,2
Total: 50 100 31 100

In structure of complaints in both groups the delicacy taped at 90 % of patients OG and at 86,1 % GS (tab. 18) prevailed. At patients in GS (77,8 %) registered depression of working capacity on 8 % more often, than in OG (70 %). PrakticheYOski with identical frequency patients complained of a night sweating as in OG (20 %), and in GS (16,7 %). At the same time the subfebrile temperature at payotsientov GS (58,3 %) took place in 1,5 times more often, than in OG (40 %). Appetite depression in OG 10 %, and in GS noticed 25 % of patients, that in 2,5 times it is more, thus weight reduction in OG (45 %) met in 1,8 times more often, than in GS (25 %). On tussis with a sputum within one month and more in OG (40,0 %) complaints showed authentically more often in 5 times, than in GS (8,3 %) (r < 0,01). При этом на сухой кашель в течение одного месяца и более пациенты ГС (8,3%) жалова­лись в 1,7 раз чаще, чем пациенты из ОГ (5%).

Thus, patients OG complained of weight reduction in 1,8 times chayoshche, and on tussis with a sputum - in 5 times more often, than in GS (r< 0,01). Вместе с тем больные ГС чаще отмечали субфебрильную температуру (в 1,5 раза) и сухой кашель (в 1,7 раз).

Table 18

Complaints of patients of the basic group and comparison group.

Complaints The basic group Comparison group
abs. % abs. %
Delicacy 18 90 31 86,1
Working capacity depression 14 70 28 77,8
Night sweating 4 20 6 16,7
Subfebrile temperature 8 40 21 58,3
Appetite depression 2 10 9 25
Weight reduction 9 45 9 25
Tussis with a sputum 8 40 3 8,3
Tussis dry 1 5 3 8,3

The catarral phenomena at auscultation of lungs in the form of rigid breath were auscultated in OG at 21,1 % of patients, that in 2,5 times more than in GS (8,7 %) (< 0,01).

ruvelichenie the sizes of a liver in OG registered in 47,3 % of cases, that in 1,5 times more often, than in GS - 32,6 % of cases. A liver edge in both groups palyopirovalsja on the average on 1,6±0,3 sm below a costal arch.

Chronic virus hepatitises in OG are found out in 74 % of patients, while in GS - at 65 %. HVGV in GS (5,7 %) met in 2,4 times more often, than in OG (2,4 %) (tab. 19). Frequency of detection HVGS in GS (74,5 %) also was above, than in OG (65,5 %) on 9 %. Thus presence of combination HVGV and HVGS in

1,6 times met in OG (32,1 %) is more often, than in GS (19,8 %), that is bound, on - visible, with prevalence in OG a parenteral way of infection of a HIV - an infection.

During radiological inspection (the survey roentgenogram of a thorax) at 100 % observed in both groups pathological izmeyoneny in a pulmonary tissue it has not been taped.

Table 19

Chronic virus hepatitises at patients of the basic group and group

Comparisons.

Kind HVG The basic group Comparison group
abs. % abs. %
IN 2 2,4 6 5,7
WITH 55 65,5 79 74,5
IN, WITH 27 32,1 21 19,8
Total 84 100 106 100

The haemoglobin content in OG has made 139,1±3,4 a g/l, in Gs - 136,7±3,1 the g/l, average levels of erythrocytes in OG and GS were identical - 4,5±0,1х 1012/l. Thus, indicators of red blood in both basic groups essentially did not differ and were within norm.

The maintenance of thrombocytes in both groups did not differ from norm, in GS the quantity of thrombocytes was a little above (224,7±11,3*10 9/l), than in OG (215,5yo9,8*109/l), differences are doubtful.

The average quantity of leucocytes in both groups essentially not otliyochalos from normal value, in OG the maintenance of leucocytes (5,7yo0,3*109/l) was insignificant more low, than in GS (5,9yo0,8*109/l).

The relative quantity of band neutrophils was insignificant above in GS (4,4±0,5 %) in comparison with OG (3,9±0,5 %), but did not exceed normal indicators, both in GS, and in OG. The average relative soderyozhanie segmented neutrophils did not exceed norm and was in identical limits in both groups (OG — 51,4±1,9 %; GS — 51,6±2,1 %).

The average relative maintenance of eosinocytes in peripheric kroyovi did not differ from norm in both groups, thus in OG level eozinofiyolov (2,7±0,4 %) was slightly above, than in GS (2,3±0,3 %).

The relative maintenance bazofilov (OG - 0,2±0,1 %; GS - 0,2±0,1 %), lymphocytes (OG — 34,2±1,7 %; GS - 33,9±2,05 %) and monocytes (OG — 7,6±0,5 %; GS - 7,6±0,5 %) in both groups also did not differ from normal value and was in identical limits.

ESR indicators were in both groups on the top border of norm, and in GS ESR level (12,3±2,01 the mm/ch) was slightly above, than at patients in OG (11,1 ±1,8 mm/ch).

Fig. 5. Maintenance SdZ-limfotsitov, СД4-лимфоцитов and СД8-лимфоцитов at patients of the basic group and comparison group.

Relative maintenance SdZ-limfotsitov in GS (79,1 ±1,4 %) prevyyoshalo normal indicators on 3 % also was authentically above, than in OG (r < 0,05), где относительное содержание СДЗ-лимфоцитов (75,03±2,5%) нахо­дилось на верхней границе нормы (рис. 5).

At the same time absolute maintenance SD of 3-lymphocytes in both grupyopah corresponded to normal value. Indicators SDZ in OG

(1536,5±126,9 kl/mkl) and in GS (1516,5±135,1 kl/mkl) were in identical limits.

Relative maintenance СД4-лимфоцитов in OG (28,1±1,5 %) was authentically above, than in GS (24,4±1,8 %) (r < 0,05). Необходимо отметить, что средний относительный уровень СД4-лимфоцитов в обеих группах был ниже нормы. Абсолютное содержание СД4-лимфоцитов в ОГ (575,4±57,6 кл/мкл) было на нижней границе нормы, в ГС (462,2±49,09 кл/мкл) - ниже нормальных значений, при этом содержание СД4-лимфоцитов в ОГ было также достоверно выше, чем в ГС (р < 0,05).

Average relative maintenance СД8-лимфоцитов in both groups exceeded normal indicators - in OG (45,8±2,3 %) on 6 %, and in GS (51,08±2,5 %) on 12 %. Relative level СД8-лимфоцитов in OG was dosyotoverno more low, than in GS (r < 0,05). Абсолютное содержание СД8-лимфоцитов в ОГ и в ГС достоверно не различалось, однако, в ГС (992,4±109,6 кл/мкл) дан­ный показатель был несколько выше, чем в ОГ (922,7±80,08 кл/мкл). В обеих группах уровень СД8-лимфоцитов превышал нормальные значения.

Average value of relation СД4/СД8 in both groups was more low noryomy, thus in OG it has made 0,7±0,06 and was authentically above, than in GS - 0,5±0,06 (r < 0,05).

Thus, men in the given research have been infected MBT in 1,5 times more often, than women. Dependences specific reaktivnoyosti from terms of a becoming infected of a HIV-infection it is not revealed. Patients osyonovnoj groups more closely and authentically contacted with tuberkulezyonymi patients is more often. At patients of the basic group laboratory signs imyomunodefitsita have appeared authentically less expressed, than at patients with a negative Mantoux test.

Chapter 4.

The analysis of efficiency of medicinal preventive maintenance of a tuberculosis at a HIV-infected

In group of patients with positive RM (OG) the average size of papules is defined at statement intradermal tuberkulinovyh assays with 2 THOSE PPD-L and 5 THOSE PPD-L. The average size of papules at statement RM with 2 THOSE has made 8,3±1,3 mm, at statement 5 THOSE is 14,9±0,9 mm (fig. 6).

Fig. 6. Level of dermal sensitivity at statement RM with 2ТЕ PPD-L and 5ТЕ PPD-L.

The size of papules at RM with 5 THOSE has appeared authentically more size of papules at RM with 2 THOSE (r < 0,001).

From 114 patients OG at 51 (44,7 %) the person has been spent profilakyotika a tubercular infection within three months by antituberculous preparations (N, R, E, Z) in various combinations.

Before preventive application himiopreparatov complaints predjavyoljali 20 (39,2 %) patients. Delicacy and working capacity depression noted 18 (90 %) and 14 (70 %) the person accordingly, while after profilakyotiki delicacy noted 10 (50 %) patients (r < 0,01) и 7 (35%) пациентов -

Working capacity depression (r < 0,01), что в 1,8 раз и в 2 раза меньше, чем до профилактики ПТП (табл. 20). На ночную потливость жаловались 4 (20%) че­ловека, после лечения ни один пациент не отмечал потливости в ночные часы (р < 0,05);

Table 20

Complaints of sick HIV-infections before tuberculosis preventive maintenance.

Complaints Before preventive maintenance After profilaktiyoki
abs. % abs. %,
Delicacy 18 90 10 50
Working capacity depression 14 70 7 35
Night sweating 4 20 0 0
Subfebrile t more than 1 month 8. 40 ’ 3 15
Appetite depression 2 10. 2 10
Weight reduction 9 45 5 25
Tussis dry more than 1 month 1 5 0 0
Tussis with a sputum more than 1 month 6 30 2 10

Frequency of revealing of subfebrile temperature (more than 1 month) has decreased from 40 % (8 people) to 15 % (3 people), i.e. In 2,6 times (r < 0,03). До химиопрфилактики 9 (45%) пациентов отмечали снижение веса, по окончании лечения в 1,8 раз меньшее (25%) количество больных продолжали отмечать снижение массы те­ла (р < 0,05). В 3 раза снизилась частота кашля с мокротой (более 1 месяца) с 30% (6 чел.) до проведения профилактического курса до 10% (2 чел.) после ле­чения (р < 0,05).

Thus, authentic depression of complaints after carrying out of a course of chemoprophylaxis has been registered.

The average size of papules before preventive maintenance at statement RM with tuberkuyolinom in a dose 2 THOSE has made 10,95±1,9 mm, 5 THOSE is 17,05±1,25 mm. In three months upon termination of a preventive course it has been executed again - RM.

The average size of papules at RM with 2 THOSE has made 6,52±1,97 mm, 5 THOSE is 12,26±1,13 mm, i.e. Has authentically decreased (r< 0,001) (рис. 7).

Fig. 7. Dynamics of level of dermal sensitivity before preventive maintenance.

That is, reception of antituberculous preparations during three mesjayotsev has made authentic impact on depression of the sizes of papules.

Before preventive maintenance at patients the immune status (fig. 8) has been surveyed. Relative maintenance SdZ-limfotsitov before and after profilaktiyoki corresponded to normal value and has made before preventive maintenance 74,07±4,7 %, after - 70,1±6,4 %. In spite of the fact that after preventive treatment maintenance SdZ-limfotsitov has slightly decreased, authentic differences is not received. Absolute maintenance SdZ-limfotsitov before preventive maintenance corresponded to norm and was in identical limits: before preventive maintenance - 1365,07±202,1 kl/mkl, after - 1342,2±262,3 kl/mkl.

Relative maintenance СД4-лимфоцитов before preventive maintenance was insignificant below norm and practically has not undergone changes: before preventive treatment — 27,8±3,2 %, after — 28,8±2,9 %. Absolute koyolichestvo СД4-лимфоцитов before preventive maintenance has made 515,7±101,3 kl/mkl, and after - 541,9±99,6 kl/mkl. Before application PTP quantity СД4-
Lymphocytes was a little below normal indicators and has slightly raised after application of preventive treatment.

80

70

60

50

gg 40

30

20

10

About

SD 3-lymphocytes SD 4-lymphocytes SD 8-lymphocytes

Fig. 8. Relative value SDZ, СД4, СД8 before preventive maintenance.

Relative maintenance СД8-лимфоцитов before application PTP slightly exceeded normal level, under influence proyofilakticheskogo treatment has not undergone special changes and has accordingly made 42,6±5,3 % and 41,8±4,6 %. Absolute maintenance СД8-лимфоцитов before preventive maintenance has made 777,2± 142,3 kl/mkl, after - 812,7±170,9 kl/mkl, that is was in limits of normal value and neznachimo has raised after application PTP.

Parity СД4/СД8 after preventive maintenance has not changed and has made 0,7±0,1, remaining below level of normal indicators.

Patients (51 people), receiving chemoprophylaxis, have been parted on four subgroups depending on quantity and a kind applied PTP.

ХП1 Have made 20 patients who within 3 months received Isoniazidum in a dose 0,3/days Isoniazidum Application in polovinnoj to a dose obuyoslovleno presence at a considerable quantity of sick HIV-encephalopathies and bad shipping of Isoniazidum in a full dose 0,6/days In ХП2 have entered 23 patients receiving within 3 months 2 PTP, namely: Isoniazidum in

To dose 0,3 g/days and rifampicin in a dose 0,45 g/days, or Ethambutolum in a dose 1,2 g/days, or Pyrazinamidum in a dose 1,0/days In HPZ have entered patients, poluyochavshie Н-0,3 g/days and rifampicin-0,45 g/days, and in ХП4 - patients, poluyochavshie Н-0,3 g/days and Е-1 ', 2 g/days or Z-Z/days also within three months.

In ХП1 distribution among patients under complaints before and after profiyolaktiki is presented to tab. 21.

Table 21

Dynamics of complaints in ХП1 before preventive maintenance by Isoniazidum.

Complaints Before preventive maintenance After profilaktiyoki
abs. % abs. %
Delicacy 5 25 3 15
Working capacity depression 5 25 2 10
Night sweating 1 5 0 0
Subfebrile t more than 1 month 3 15 2 10
Appetite depression 0 0 0 0
Weight reduction 3 15 2 10
Tussis dry more than 1 month 0 0 0 0
Tussis with a sputum more than 1 month 2 10 1 5

Before preventive maintenance the greatest quantity of patients and with identical chasyototoj was shown by complaints to delicacy (25 %) and working capacity depression (25 %). In 1,6 times met subfebrile temperature more than one month (15 %) and weight reduction (15 %) less often. In 2,5 times tussis with mokyorotoj (10 %) was less often taped and in 5 times is more rare (5 %) - a night sweating.

After preventive treatment in 1,7 times delicacy (15 %) was less often taped, in 2,5 times is more rare — working capacity depression (10 %). In 1,5 times umenyoshilis complaints to subfebrile temperature (10 %) and weight reduction (10 %). One (5 %) the patient continued to note tussis with a sputum.

It is received.

The average size of papules at statement RM with 2 THOSE in ХП1 has made 9,5±2,9 mm, 5 THOSE is 16,5±1,5 mm. In three months during which patsienyoty accepted only Isoniazidum in a dose 0,3 g/days, it has been executed kontrolyonaja RM. The average size of papules in 3 months has made: RM 2 THOSE is 8,6±2,8 mm, 5 THOSE is 15,8±2,3 mm (fig. 9).

2 THOSE 5 THOSE

Fig. 9. Dynamics RM against preventive maintenance by Isoniazidum.

Thus, in three months of reception Н-0,3 g/days the size of papules dosyotoverno has not changed.

Before preventive reception of Isoniazidum at patients was obyosledovan the immune status.

Relative maintenance SdZ-limfotsitov before preventive maintenance corresponded to normal value on the top border of norm and nahodiyolos in identical limits: before preventive maintenance - 72,3±14,2 %, after - 72,6±14,2 %. Absolute quantity SdZ-limfotsitov before and after profilakyotiki corresponded to norm and has made before preventive maintenance - 1658,8±625,2 kl/mkl, after - 1359,1±588,7 kl/mkl. In spite of the fact that after

Preventive treatment average maintenance SdZ-limfotsitov neznachiyotelno has decreased, authentic differences is not received.

Relative maintenance СД4-лимфоцитов before preventive maintenance was insignificant below norm, but has a little raised after reception izoyoniazida: before preventive treatment - 26,0±3,1 %, after - 29,4±2,4 %. AbYOsoljutnoe quantity СД4-лимфоцитов before preventive maintenance has made 577,8±169,6 kl/mkl, and after - 597,9±188,1 kl/mkl, and, thus, before application PTP was on the bottom border of norm and has slightly raised after application of preventive treatment.

Relative maintenance СД8-лимфоцитов before application PTP slightly exceeded normal level, and under the influence of preventive treatment has not undergone changes and corresponded 42,1±10,8 % and 41,1±8,3 %. Absolute number СД8-лимфоцитов to profilaktiyoki has made 972,7±168,3 kl/mkl, after - 761,1±109,1 kl/mkl, that is prevyyoshalo normal value before preventive maintenance and has decreased to norm after leyochenija Isoniazidum.

Value of parity СД4/СД8 after preventive maintenance a little povyyosilos (0,75±0,3) in comparison with initial level (0,68±0,2), but remains below normal indicators.

Clinical example:

Patient TS, 36 years, is on the dispensary account in the Center on proyofilaktike and struggle against AIDS within nine years with the diagnosis: В-23, stayodija III, an encephalopathy of II item, an oral candidiasis, a hairy leukoplakia of tongue, the TSMV-INFECTION, a latent stage. From the epidemiological anamnesis it is known, that within one year the patient was in periodic konyotakte with familiar, sick of the active form of a pulmonary tuberculosis. At obsleyodovanii the patient showed complaints to delicacy, depression rabotosposobnoyosti, subfebrile temperature within last month, a weight loss on 4 kg for the past half a year, appetite depression. At auscultation the catarral phenomena were not auscultated. On the survey roentgenogram of a thorax ocha -

govye and infiltrativnye changes in lungs are not taped. As a result poyostanovki RM the sizes of papules are defined: on a tuberculin in a dose 2 THEY are 11 mm, 5 THEY be 14 mm. The clinical analysis of blood: haemoglobin - 113 g/l, erythrocytes

- 3,19>

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A source: Tursunova Natalia Aleksandrovna. TUBERCULINODIAGNOSTIC AND CHEMIOPROPHYLAXIS OF TUBERCULOSIS IN HIV-INFECTED PATIENTS. St. Petersburg 2006. 2006

More on topic 3.3. The comparative analysis of sick HIV-infections with positive and negativedermal reaction to a tuberculin:

  1. Preventive maintenance of a tuberculosis at sick HIV-infections
  2. the Pathogenesis of a tuberculosis at sick HIV-infections.
  3. Clinic and features of diagnostics of a tuberculosis at sick HIV-infections
  4. Chapter 5. Sensitivity level to a tuberculin at sick active tuberkuyolezom lungs and a HIV-infection
  5. Morphological implications of a tuberculosis at sick HIV-infections
  6. Chapter 6. The comparative analysis of epidemiological, clinical and laboratory indicators sick of a tuberculosis in a combination to a HIV and VG in Russia (OG-R) and Vietnam (OG-IN)
  7. Clinic of a tuberculosis at sick HIV-infections
  8. Features of treatment of a tuberculosis at sick HIV-infections
  9. the Comparative analysis of patients OG with a positive Mantoux test on 2 THOSE and 5 THOSE with patients of a subgroup of the basic group with otritsayotelnoj a Mantoux test on 2 THOSE and positive RM on 5 THOSE
  10. Chapter 4 of Feature of clinicoradiological implications of a tuberculosis of organs of breath at sick HIV-infections
  11. Chapter 5 of Feature of treatment and outcomes of a tuberculosis of organs of breath at sick HIV-infections
  12. Head Z Specific reactance on a tuberculin at patients from a HIV - as an infection
  13. the characteristic of patients of the basic group with positive reyoaktsiej on a tuberculin
  14. Le Than Toan. the EPIDEMIOLOGICAL And CLINICO-LABORATORY CHARACTERISTIC of VIRUS HEPATITISES And a HIV - INFECTIONS At SICK of the TUBERCULOSIS. The dissertation on competition of a scientific degree of the candidate of medical sciences. St.-Petersburg -,
  15. the Comparative analysis of patients of investigated group depending on time of revealing of an active tuberculosis and an infection HIV -
  16. the comparative characteristic of groups of patients with active tuberkuyolezom organs of breath without a HIV-infection (TB) and with a HIV-infection (ТБ+ВИЧ)
  17. Chapter 4 the Comparative characteristic clinico-immunologicheskih HIV-infection indicators, sochetannoj with a tuberculosis and a HIV-infection without a tuberculosis
  18. the Comparative characteristic of a current of tubercular process at patients of the basic group (a tuberculosis in a combination to a HIV-infection) and in control group (a tuberculosis without a HIV-infection)
  19. sensitivity level to a tuberculin at organs of breathsick of a tuberculosis depending on terms of revealing of a tuberculosis and a HIV-infection
  20. Chapter 1. The analysis of data of the literature by a comparative estimation of level of efficiency and safety of various operative measures at sick of the localised cancer of a prostate