4. Synthesis and research of physical and chemical properties new optically active kompleksonov

Let's consider condensation aminodikarbonovyh acids with galogenkarbonovymi acids on which basis have been received new optically active kompleksony, derivatives of succinic and glutaric acids.

Interaction reaction aminodikarbonovyh acids with galogenkarbonovymi acids is applied to synthesis kompleksonov monoaminovogo type, derivative dicarboxylic acids.

This way of synthesis it is used widespread aminodikarbonovye acids.

The general schema of synthesis looks so:

Where R1, R2 - the radicals containing a carboxyl group (including and a case, when Ri = R2).

As galogenkarbonovaja acid during reaction is exposed to significant hydrolysis it is necessary for entering into the reactionary environment with 1,5 - 2 multiple surplus. This surplus is entered by small portions during all time of synthesis.

By this method it has been received - - (karboksimetil) - asparaginovajakislota (L-КМАК, H3X) [96], E-ShChkarboksimetil) - asparaginovajakislota (D-КМАК, H3Y) and L-L -

(karboksimetil) glutaminovajakislota (L-КМГК, H3Z).

In all cases the alkaline condition in a reaction mixture is supported by lithium oxyhydroxide, and acidifying of a solution after synthesis (for transfer kompleksona in the sour form) is carried out by the hydrobromide acid.

This reception provides reception LiBr as inorganic salt, as neutralisation resultant of reaction. Unlike NaCl or NaBr lithium the bromous we will dissolve in methanol, acetone and ethoxy ethane. This property LiBr allows to separate easily a reaction finished product (komplekson) from inorganic salts vysazhdeniem in methanol, acetone, etc. [97, 98].


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A source: Biberina Evgenie Sergeevna. COMPLEX FORMATION OF SOME ZE-METALS WITH L-, D-FORMES H- (CARBOXYMETHYL) ASPARAGINOUS AND L-N- (CARBOXYMETHYL) ACID GLUTAMINE. Thesis for the degree of candidate of chemical sciences. Tver - 2018. 2018

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